People

Dezheng Huo, PhD

Dr. Huo’s research interests focus on the genetic, molecular, and environmental factors underlying etiology, prognosis, and treatment of cancers, particularly as they relate to cancer in underserved populations. His research spans across several areas of cancer epidemiology and clinical epidemiology, including:



1. Genetic epidemiology of breast cancer, particular in women of African ancestry with the use of genome-wide association and whole genome sequencing approach.



2. Environmental and lifestyle factors for breast cancer etiology in African women and risk prediction model building, and strategy for cancer screening.



3. Epigenetics and non-coding RNAs, such as microRNAs in relationship to cancer prognosis and survival.



4. Investigation of the utilization and effectiveness of cancer treatment in real world using big data.



5. Prenatal exposure to diethylstilbestrol and clear cell adenocarcinoma of vagina and cervix, as well as other health conditions in later life.



6. Health disparity in breast cancer outcomes in multiethnic patient cohort study with multi-dimensional data.

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach.
Gao G, Zhao F, Ahearn TU, Lunetta KL, Troester MA, Du Z, Ogundiran TO, Ojengbede O, Blot W, Nathanson KL, Domchek SM, Nemesure B, Hennis A, Ambs S, McClellan J, Nie M, Bertrand K, Zirpoli G, Yao S, Olshan AF, Bensen JT, Bandera EV, Nyante S, Conti DV, Press MF, Ingles SA, John EM, Bernstein L, Hu JJ, Deming-Halverson SL, Chanock SJ, Ziegler RG, Rodriguez-Gil JL, Sucheston-Campbell LE, Sandler DP, Taylor JA, Kitahara CM, O'Brien KM, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Wang Q, Figueroa J, Biritwum R, Adjei E, Wiafe S. Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach. Hum Mol Genet. 2022 09 10; 31(18):3133-3143.
PMID: 35554533

Oncology Training Needs Assessment Among Health Care Professionals in Nigeria.
Adejumo PO, Oluwasanu MM, Ntekim A, Awolude OA, Kotila OA, Aniagwu T, Brown BJ, Dzekem BS, Duncan S, Tito-Ilori M, Ajani O, Lee SM, Babalola CP, Ojengbede O, Huo D, Hammad N, Olopade OI. Oncology Training Needs Assessment Among Health Care Professionals in Nigeria. JCO Glob Oncol. 2022 05; 8:e2200017.
PMID: 35594507

Differences in somatic TP53 mutation type in breast tumors by race and receptor status.
Pollock NC, Ramroop JR, Hampel H, Troester MA, Conway K, Hu JJ, Freudenheim JL, Olopade OI, Huo D, Ziv E, Neuhausen SL, Stevens P, McElroy JP, Toland AE. Differences in somatic TP53 mutation type in breast tumors by race and receptor status. Breast Cancer Res Treat. 2022 Apr; 192(3):639-648.
PMID: 35286522

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes.
Ansari-Pour N, Zheng Y, Yoshimatsu TF, Sanni A, Ajani M, Reynier JB, Tapinos A, Pitt JJ, Dentro S, Woodard A, Rajagopal PS, Fitzgerald D, Gruber AJ, Odetunde A, Popoola A, Falusi AG, Babalola CP, Ogundiran T, Ibrahim N, Barretina J, Van Loo P, Chen M, White KP, Ojengbede O, Obafunwa J, Huo D, Wedge DC, Olopade OI. Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes. Nat Commun. 2021 11 26; 12(1):6946.
PMID: 34836952

Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.
Scannell Bryan M, Ogundiran T, Ojengbede O, Zheng W, Blot W, Domcheck S, Hennis A, Nemesure B, Ambs S, Olopade OI, Huo D. Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis. J Epidemiol Community Health. 2022 04; 76(4):411-417.
PMID: 34706928

Hypofractionated Radiation Therapy for Breast Cancer: Financial Risk and Expenditures in the United States, 2008 to 2017.
Saulsberry L, Liao C, Huo D. Hypofractionated Radiation Therapy for Breast Cancer: Financial Risk and Expenditures in the United States, 2008 to 2017. Int J Radiat Oncol Biol Phys. 2022 03 01; 112(3):654-662.
PMID: 34637883

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.
Du Z, Gao G, Adedokun B, Ahearn T, Lunetta KL, Zirpoli G, Troester MA, Ruiz-Narváez EA, Haddad SA, PalChoudhury P, Figueroa J, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Mancuso N, Press MF, Deming SL, Rodriguez-Gil JL, Yao S, Ogundiran TO, Ojengbe O, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Sandler DP, Taylor JA, Wang Q, Weinberg CR, Kitahara CM, Blot W, Nathanson KL, Hennis A, Nemesure B, Ambs S, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Olshan AF, Ambrosone CB, Olopade OI, Yarney J, Awuah B, Wiafe-Addai B, Conti DV. Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry. J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176.
PMID: 33769540

Assessment of Breast Cancer Management in Sub-Saharan Africa.
Vanderpuye V, Dadzie MA, Huo D, Olopade OI. Assessment of Breast Cancer Management in Sub-Saharan Africa. JCO Glob Oncol. 2021 09; 7:1593-1601.
PMID: 34843373

The impact of coronavirus disease 2019 on the quality of life and treatment disruption of patients with breast cancer in a multiethnic cohort.
Zhao F, Henderson TO, Cipriano TM, Copley BL, Liu M, Burra R, Birch SH, Olopade OI, Huo D. The impact of coronavirus disease 2019 on the quality of life and treatment disruption of patients with breast cancer in a multiethnic cohort. Cancer. 2021 11 01; 127(21):4072-4080.
PMID: 34292583

The impact of site-specific digital histology signatures on deep learning model accuracy and bias.
Howard FM, Dolezal J, Kochanny S, Schulte J, Chen H, Heij L, Huo D, Nanda R, Olopade OI, Kather JN, Cipriani N, Grossman RL, Pearson AT. The impact of site-specific digital histology signatures on deep learning model accuracy and bias. Nat Commun. 2021 07 20; 12(1):4423.
PMID: 34285218

View All Publications

Study section of P01
NIH/NCI
2019

Study section of R01/R21
NIH/NCI
2018 - 2020

Study section of U01, H3Africa
NIH/NHGRI
2017

Study section of P01
NIH/NCI
2017

Runner-up in the Up For A Challenge – Stimulating Innovation in Breast Cancer Genetic Epidemiology
National Cancer Institute
2016

Study section of U54
NIH/NIMHD
2015

Distinguished Investigator Junior Award
University of Chicago
2014

Breast Cancer Research Program study section
U.S. Army Medical Research and Materiel Command
2013 - 2014

Breast Cancer Research Program study section
U.S. Army Medical Research and Materiel Command
2010

Breast Cancer Research Program study section
U.S. Army Medical Research and Materiel Command
2008

Delta Omega
National Honor Society in Public Health
2005

Haenszel Award for Excellence in Research
University of Illinois at Chicago
2005

Student Travel Award
University of Illinois at Chicago
2000